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Peptide record

TPDB31803

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB31803
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GPLTILHINDVHAAFEQFNT
Physicochemical Analysis
C102H153N27O30
RCKMSWY
ANHILFT
2237.50
5.05
2
2
9
-2
3.06
0.135
102.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
2
A
0
R
2
N
1
D
0
C
1
E
1
Q
1
G
2
H
2
I
2
L
0
K
0
M
2
F
1
P
0
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 0 E: 1 Q: 1 G: 1 H: 2 I: 2 L: 2 K: 0 M: 0 F: 2 P: 1 S: 0 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C102H153N27O30
2237.50
5.05
-2
3.06
0.135
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that shows cardiotoxicity on isolated guinea pig heart and auricle and neurotoxicity on isolated rat phrenic nerve diaphragm. Shows antiosteoporosis activity in experimental rats. Also induces apoptosis against human leukemic cells (U937 and K562). Has no effect on normal human lymphocytes. Apoptosis has been evidenced from damaged nuclei, cell cycle arrest at sub G1 phase, increase of early apoptotic cells, augmentation of DNA fragmentation and also a reduction of telomerase activity. Also elicits loss of mitochondrial membrane potential (MMP) which induces cytochrome c release in cytosol, decreases heat shock protein (HSP) 70 and 90 expression, activates caspase-9, caspase-3, induces poly (ADP-ribose) polymerase (PARP) cleavage, and up-regulates caspase-3. {ECO:0000269|PubMed:19800909, ECO:0000269|PubMed:19913524}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Deccanometrus bengalensis (Indian black scorpion) (Heterometrus bengalensis)
Neurotoxin
Toxin that shows cardiotoxicity on isolated guinea pig heart and auricle and neurotoxicity on isolated rat phrenic nerve diaphragm. Shows antiosteoporosis activity in experimental rats.
Bengalin
scorpion
Evidence at protein level
Apoptosis Cardiotoxin Cell cycle Direct protein sequencing Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19800909, ECO:0000305|PubMed:19913524}.
Additional Detail Fields 6 fields
Apoptosis Cardiotoxin Cell cycle Direct protein sequencing Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Bengalin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19800909, ECO:0000305|PubMed:19913524}.
scorpion