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Peptide record

TPDB31782

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB31782
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GNCLELGEYCDGSKDDCQCCRDNAYCGCDIF
Physicochemical Analysis
C135H202N38O52S7
HMPTWV
C
3413.73
3.57
2
7
7
-5
7.29
-0.458
40.97
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
98.28
13
Residue Composition
number
1
A
1
R
2
N
5
D
7
C
2
E
1
Q
4
G
0
H
1
I
2
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 5 C: 7 E: 2 Q: 1 G: 4 H: 0 I: 1 L: 2 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
31
C135H202N38O52S7
3413.73
3.57
-5
7.29
-0.458
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxins are antagonists of voltage-gated calcium channels (Cav)..
U14-ctenitoxin-Co1a (U14-CNTX-Co1a) (Neurotoxin Oc M20-3)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
U14-ctenitoxin-Co1a (U14-CNTX-Co1a) (Neurotoxin Oc M20-3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider