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Peptide record

TPDB31781

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB31781
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GNCKCDDEGPYVRTAPLTGYVDLGYCNEGWEKCASYYSPIAECCRKKK
Physicochemical Analysis
C232H352N62O74S6
QHMF
C
5386.08
6.25
7
7
14
-0
11.33
-0.756
42.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13325
247.40
17
Residue Composition
number
3
A
2
R
2
N
3
D
6
C
4
E
0
Q
5
G
0
H
1
I
2
L
5
K
0
M
0
F
3
P
2
S
2
T
1
W
5
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 3 C: 6 E: 4 Q: 0 G: 5 H: 0 I: 1 L: 2 K: 5 M: 0 F: 0 P: 3 S: 2 T: 2 W: 1 Y: 5 V: 2
Chemical Descriptors
48
C232H352N62O74S6
5386.08
6.25
-0
11.33
-0.756
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Delta-stichotoxin-Hcr1a]: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. Specifically inhibits mammalian Nav1.3/SCN3A and Nav1.6/SCN8A sodium channels, as well as insect BgNav1 and VdNav1 sodium channels. {ECO:0000269|PubMed:33368037}. FUNCTION: [Delta-stichotoxin-Hcr1f]: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. Specifically inhibits mammalian Nav1.2/SCN3A (low inhibition) and Nav1.6/SCN8A sodium channels, as well as insect BgNav1 and VdNav1 sodium channels. {ECO:0000269|PubMed:33368037}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
[Delta-stichotoxin-Hcr1a]: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. Specifically inhibits mammalian Nav1.3/SCN3A and Nav1.6/SCN8A sodium channels, as well as insect BgNav1 and VdNav1 sodium channels.. FUNCTION: [Delta-stichotoxin-Hcr1f]: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process.
Delta-stichotoxin-Hcr1a (Delta-SHTX-Hcr1a) (Neurotoxin III) (RTX-III) (Rm3) [Cleaved into: Delta-stichotoxin-Hcr1f (Delta-SHTX-Hcr1f) (RTX-VI)]
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hcr1a (Delta-SHTX-Hcr1a) (Neurotoxin III) (RTX-III) (Rm3) [Cleaved into: Delta-stichotoxin-Hcr1f (Delta-SHTX-Hcr1f) (RTX-VI)]
sea anemone