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Peptide record

TPDB31780

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB31780
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GNCKCDDEGPNVRTAPLTGYVDLGYCNEGWEKCASYYSPIAECCRKKK
Physicochemical Analysis
C227H349N63O74S6
QHMF
C
5337.01
6.25
7
7
13
-0
12.69
-0.802
42.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
221.75
17
Residue Composition
number
3
A
2
R
3
N
3
D
6
C
4
E
0
Q
5
G
0
H
1
I
2
L
5
K
0
M
0
F
3
P
2
S
2
T
1
W
4
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 3 C: 6 E: 4 Q: 0 G: 5 H: 0 I: 1 L: 2 K: 5 M: 0 F: 0 P: 3 S: 2 T: 2 W: 1 Y: 4 V: 2
Chemical Descriptors
48
C227H349N63O74S6
5337.01
6.25
-0
12.69
-0.802
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:2412579). Its toxicity is greater than that of RpII (AC P01534) (PubMed:2412579). {ECO:0000269|PubMed:2412579}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction (PubMed:2412579). Its toxicity is greater than that of RpII (AC P01534) (PubMed:2412579)..
Delta-stichotoxin-Hmg4b (Delta-SHTX-Hmg4b) (Delta-stichotoxin-Rpa1b) (Delta-SHTX-Rpa1b) (RpIII) (Toxin III)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hmg4b (Delta-SHTX-Hmg4b) (Delta-stichotoxin-Rpa1b) (Delta-SHTX-Rpa1b) (RpIII) (Toxin III)
sea anemone