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Peptide record

TPDB31779

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31779
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GNCKCDDEGPNVRTAPLTGYVDLGYCNEGWEKCASYYSPIAECCRKK
Physicochemical Analysis
C221H337N61O73S6
QHMF
C
5208.83
4.89
6
7
13
-1
11.70
-0.736
43.62
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
227.21
17
Residue Composition
number
3
A
2
R
3
N
3
D
6
C
4
E
0
Q
5
G
0
H
1
I
2
L
4
K
0
M
0
F
3
P
2
S
2
T
1
W
4
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 3 C: 6 E: 4 Q: 0 G: 5 H: 0 I: 1 L: 2 K: 4 M: 0 F: 0 P: 3 S: 2 T: 2 W: 1 Y: 4 V: 2
Chemical Descriptors
47
C221H337N61O73S6
5208.83
4.89
-1
11.70
-0.736
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. {ECO:0000250|UniProtKB:P30832}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process..
Delta-stichotoxin-Hcr1d (Delta-SHTX-Hcr1d) (Neurotoxins V) (RTX-V) (Rm5)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hcr1d (Delta-SHTX-Hcr1d) (Neurotoxins V) (RTX-V) (Rm5)
sea anemone