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Peptide record

TPDB31778

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB31778
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GNCKCDDEGPNVRTAPLTGYVDLGYCNEGWDKCASYYSPIAECCRKKK
Physicochemical Analysis
C226H347N63O74S6
QHMF
C
5322.98
6.23
7
7
13
-0
11.90
-0.802
42.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
222.34
17
Residue Composition
number
3
A
2
R
3
N
4
D
6
C
3
E
0
Q
5
G
0
H
1
I
2
L
5
K
0
M
0
F
3
P
2
S
2
T
1
W
4
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 3 D: 4 C: 6 E: 3 Q: 0 G: 5 H: 0 I: 1 L: 2 K: 5 M: 0 F: 0 P: 3 S: 2 T: 2 W: 1 Y: 4 V: 2
Chemical Descriptors
48
C226H347N63O74S6
5322.98
6.23
-0
11.90
-0.802
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process. {ECO:0000250|UniProtKB:P30832}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to site 3 of voltage-gated sodium channels and inhibits the inactivation process..
Delta-stichotoxin-Hcr1c (Delta-SHTX-Hcr1c) (Neurotoxins IV) (RTX-IV) (Rm4)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-stichotoxin-Hcr1c (Delta-SHTX-Hcr1c) (Neurotoxins IV) (RTX-IV) (Rm4)
sea anemone