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Peptide record

TPDB31720

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB31720
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GLIRPSKRCIGGGDPCEFHRPYTCCSGYCIVFVCA
Physicochemical Analysis
C165H255N47O45S6
NQMW
C
3809.49
8.02
5
2
11
+2
2.33
0.251
64.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
88.07
11
Residue Composition
number
1
A
3
R
0
N
1
D
6
C
1
E
0
Q
5
G
1
H
3
I
1
L
1
K
0
M
2
F
3
P
2
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 5 H: 1 I: 3 L: 1 K: 1 M: 0 F: 2 P: 3 S: 2 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
35
C165H255N47O45S6
3809.49
8.02
+2
2.33
0.251
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion channels. {ECO:0000305}.

Target

proton-gated sodium channel / ASIC

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Californiconus californicus (California cone) (Conus californicus)
Neurotoxin Ion channel impairing toxin
Probable neurotoxin with unknown target. Possibly targets ion channels..
Conotoxin Cal6.1f
cone snail
Conotoxin O1 superfamily
Evidence at transcript level
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
Additional Detail Fields 7 fields
Cleavage on pair of basic residues Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at transcript level
Conotoxin O1 superfamily
Conotoxin Cal6.1f
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:21172372}.
cone snail