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Peptide record

TPDB31717

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB31717
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GLIDVRCYDSRQCWIACKKVTGSTQGKCQNKQCRCY
Physicochemical Analysis
C172H281N55O52S6
EHMFP
C
4143.82
8.87
7
2
9
+5
5.78
-0.647
51.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
213.69
17
Residue Composition
number
1
A
3
R
1
N
2
D
6
C
0
E
4
Q
3
G
0
H
2
I
1
L
4
K
0
M
0
F
0
P
2
S
2
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 2 C: 6 E: 0 Q: 4 G: 3 H: 0 I: 2 L: 1 K: 4 M: 0 F: 0 P: 0 S: 2 T: 2 W: 1 Y: 2 V: 2
Chemical Descriptors
36
C172H281N55O52S6
4143.82
8.87
+5
5.78
-0.647
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Augments responses to direct muscle stimulation probably by blocking calcium-activated potassium channels.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Augments responses to direct muscle stimulation probably by blocking calcium-activated potassium channels.
Potassium channel toxin alpha-KTx 16.5 (Lqh 15-1) (Toxin 15-1) (alpha-KTx 1.7)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Potassium channel toxin alpha-KTx 16.5 (Lqh 15-1) (Toxin 15-1) (alpha-KTx 1.7)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion