Back to search

Peptide record

TPDB31715

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB31715
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GLIDVKCYASRECWEPCRKVTGSGQAKCQNNQCRCY
Physicochemical Analysis
C169H270N54O53S6
HMF
C
4098.69
8.30
6
3
9
+3
7.89
-0.736
43.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
216.04
16
Residue Composition
number
2
A
3
R
2
N
1
D
6
C
2
E
3
Q
3
G
0
H
1
I
1
L
3
K
0
M
0
F
1
P
2
S
1
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 1 C: 6 E: 2 Q: 3 G: 3 H: 0 I: 1 L: 1 K: 3 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 2 V: 2
Chemical Descriptors
36
C169H270N54O53S6
4098.69
8.30
+3
7.89
-0.736
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Poorly competes with (125)I-kaliotoxin binding on rat brain synaptosome (IC(50)>100 nM). Is a poor Kv1.3 ligand (PubMed:23523531). May have as real target KCa1.1/KCNMA1 channel (By similarity). Shows weak toxicity on mice (PubMed:23523531). {ECO:0000250|UniProtKB:Q9NBG9, ECO:0000269|PubMed:23523531}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus paris (Scorpion) (Buthus occitanus paris)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Poorly competes with (125)I-kaliotoxin binding on rat brain synaptosome (IC(50)>100 nM). Is a poor Kv1.3 ligand (PubMed:23523531).
Potassium channel toxin alpha-KTx 16.8 (Toxin BoP1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily
Potassium channel toxin alpha-KTx 16.8 (Toxin BoP1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion