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Peptide record

TPDB31687

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB31687
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GKCGEINGSCDECYGGSVTCDCY
Physicochemical Analysis
C92H139N25O38S5
ARQHLMFPW
CG
2363.56
3.59
1
4
4
-3
5.04
-0.309
29.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3230
136.66
11
Residue Composition
number
0
A
0
R
1
N
2
D
5
C
2
E
0
Q
5
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
2
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 2 C: 5 E: 2 Q: 0 G: 5 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
23
C92H139N25O38S5
2363.56
3.59
-3
5.04
-0.309
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects. {ECO:0000250|UniProtKB:P59367}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects..
U1-ctenitoxin-Co1a (U1-CNTX-Co1a) (Neurotoxin Oc F17-11)
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
U1-ctenitoxin-Co1a (U1-CNTX-Co1a) (Neurotoxin Oc F17-11)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider