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Peptide record

TPDB31685

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB31685
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GKCGDINAPCKAECDCCGYTTCDCYWGN
Physicochemical Analysis
C120H177N33O43S7
RQHLMFSV
C
2994.34
3.97
2
4
6
-2
3.24
-0.404
21.07
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
295.72
13
Residue Composition
number
2
A
0
R
2
N
3
D
7
C
1
E
0
Q
4
G
0
H
1
I
0
L
2
K
0
M
0
F
1
P
0
S
2
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 3 C: 7 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 2 W: 1 Y: 2 V: 0
Chemical Descriptors
28
C120H177N33O43S7
2994.34
3.97
-2
3.24
-0.404
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects. {ECO:0000250|UniProtKB:P59367}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects..
U15-ctenitoxin-Co1a (U15-CNTX-Co1a) (Neurotoxin Oc M33-7)
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
U15-ctenitoxin-Co1a (U15-CNTX-Co1a) (Neurotoxin Oc M33-7)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider