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Peptide record

TPDB31681

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB31681
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GKCADAWKSCDNLPCCVVNGYSRTCMCSANRCNCEETKKLREHFG
Physicochemical Analysis
C204H325N65O66S9
QI
C
5032.76
7.85
8
5
11
+2
11.14
-0.589
36.89
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
148.82
18
Residue Composition
number
3
A
3
R
4
N
2
D
8
C
3
E
0
Q
3
G
1
H
0
I
2
L
4
K
1
M
1
F
1
P
3
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 3 N: 4 D: 2 C: 8 E: 3 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 4 M: 1 F: 1 P: 1 S: 3 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
45
C204H325N65O66S9
5032.76
7.85
+2
11.14
-0.589
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Neurotoxin. Causes rapid general flaccid paralysis and death in mice at dose levels of 5 ug per mouse. {ECO:0000269|Ref.2, ECO:0000305}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria keyserlingi (Brazilian wandering spider) (Ctenus keyserlingii)
Neurotoxin
Neurotoxin. Causes rapid general flaccid paralysis and death in mice at dose levels of 5 ug per mouse..
U1-ctenitoxin-Pk1a (U1-CNTX-Pk1a) (Neurotoxin PKTx19C5)
spider
Neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Knottin Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily
U1-ctenitoxin-Pk1a (U1-CNTX-Pk1a) (Neurotoxin PKTx19C5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16278100, ECO:0000269|Ref.2, ECO:0000305}.
spider