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Peptide record

TPDB31677

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31677
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GIACLCDSDGPSVRGNTLSGTYWLAGCPSGWHNCKSSGQLIGACCKQ
Physicochemical Analysis
C201H314N60O65S6
EMF
G
4803.43
7.64
4
2
13
+1
0.87
-0.072
62.34
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
267.83
19
Residue Composition
number
3
A
1
R
2
N
2
D
6
C
0
E
2
Q
8
G
1
H
2
I
4
L
2
K
0
M
0
F
2
P
6
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 2 G: 8 H: 1 I: 2 L: 4 K: 2 M: 0 F: 0 P: 2 S: 6 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
47
C201H314N60O65S6
4803.43
7.64
+1
0.87
-0.072
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Produces a positive inotropic effect in mammalian heart muscle. Modifies current passing through the fast sodium channel (Nav) in neuroblastoma cells, leading to delayed and incomplete inactivation. Paralyzes the shore crab (C.maenas) by tetanic contractions after intramuscular injection. {ECO:0000269|PubMed:11072049}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Produces a positive inotropic effect in mammalian heart muscle. Modifies current passing through the fast sodium channel (Nav) in neuroblastoma cells, leading to delayed and incomplete inactivation.
Delta-actitoxin-Ael1b (Delta-AITX-Ael1b) (Toxin APE 1-1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Ael1b (Delta-AITX-Ael1b) (Toxin APE 1-1)
sea anemone