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Peptide record

TPDB31666

Neurotoxin Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB31666
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 44-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GHVSCGKDGRACDYHADCCNCCLGGICKPSTSWIGCSTNVFLTR
Physicochemical Analysis
C190H297N59O61S8
EQM
C
4640.29
7.51
6
3
11
+1
3.72
-0.018
53.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
161.41
18
Residue Composition
number
2
A
2
R
2
N
3
D
8
C
0
E
0
Q
6
G
2
H
2
I
2
L
2
K
0
M
1
F
1
P
4
S
3
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 3 C: 8 E: 0 Q: 0 G: 6 H: 2 I: 2 L: 2 K: 2 M: 0 F: 1 P: 1 S: 4 T: 3 W: 1 Y: 1 V: 2
Chemical Descriptors
44
C190H297N59O61S8
4640.29
7.51
+1
3.72
-0.018
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus figulinus (Fig cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like Fi11.1
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.11
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like Fi11.1 Iota-conotoxin-like R11.11
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail