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Peptide record

TPDB31662

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB31662
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GHVPCGKDGRKCGYHTHCCNCCLSGICKPSTSLIGCSTSSFT
Physicochemical Analysis
C177H283N55O57S8
AEQMW
C
4350.01
8.10
7
1
7
+3
4.95
-0.088
44.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
45.75
20
Residue Composition
number
0
A
1
R
1
N
1
D
8
C
0
E
0
Q
6
G
3
H
2
I
2
L
3
K
0
M
1
F
2
P
6
S
4
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 8 E: 0 Q: 0 G: 6 H: 3 I: 2 L: 2 K: 3 M: 0 F: 1 P: 2 S: 6 T: 4 W: 0 Y: 1 V: 1
Chemical Descriptors
42
C177H283N55O57S8
4350.01
8.10
+3
4.95
-0.088
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.16
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like R11.16
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail