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Peptide record

TPDB31661

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB31661
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GHVPCGKDGRKCGYHADCCNCCLSGICKPSTSWTGCSTSTVQLTR
Physicochemical Analysis
C191H307N61O63S8
EMF
C
4722.39
8.10
7
2
8
+3
6.11
-0.313
41.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
158.61
21
Residue Composition
number
1
A
2
R
1
N
2
D
8
C
0
E
1
Q
6
G
2
H
1
I
2
L
3
K
0
M
0
F
2
P
5
S
5
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 8 E: 0 Q: 1 G: 6 H: 2 I: 1 L: 2 K: 3 M: 0 F: 0 P: 2 S: 5 T: 5 W: 1 Y: 1 V: 2
Chemical Descriptors
45
C191H307N61O63S8
4722.39
8.10
+3
6.11
-0.313
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.10
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like R11.10
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail