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Peptide record

TPDB31595

Neurotoxin Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB31595
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 23-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GHACYRNCWREGNDEETCKERCG
Physicochemical Analysis
C107H162N38O38S4
QILMFPSV
CE
2716.94
5.49
5
5
3
-1
10.78
-1.626
4.35
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7240
266.48
8
Residue Composition
number
1
A
3
R
2
N
1
D
4
C
4
E
0
Q
3
G
1
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 4 E: 4 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
23
C107H162N38O38S4
2716.94
5.49
-1
10.78
-1.626
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Potassium channel toxin kappa-KTx 1.1]: Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709). Also shows a weak inhibitory activity on the plant pathogen F.culmorum growth (IC(50)=18.8-37.7 uM) (PubMed:27578329). {ECO:0000269|PubMed:12034709, ECO:0000269|PubMed:23726856, ECO:0000269|PubMed:27578329}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chersonesometrus fulvipes (Indian black scorpion) (Heterometrus fulvipes)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
[Potassium channel toxin kappa-KTx 1.1]: Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709).
Potassium channel toxin kappa-KTx 1.2 (Kappa-hefutoxin 2) (Kappa-HfTx2) [Cleaved into: Potassium channel toxin kappa-KTx 1.1 (Kappa-hefutoxin 1) (Kappa-HfTx1)]
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 1 subfamily
Evidence at protein level
3D-structure Amidation Antimicrobial Direct protein sequencing Disulfide bond Fungicide Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12034709}.
Additional Detail Fields 7 fields
3D-structure Amidation Antimicrobial Direct protein sequencing Disulfide bond Fungicide Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 1 subfamily
Potassium channel toxin kappa-KTx 1.2 (Kappa-hefutoxin 2) (Kappa-HfTx2) [Cleaved into: Potassium channel toxin kappa-KTx 1.1 (Kappa-hefutoxin 1) (Kappa-HfTx1)]
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12034709}.
scorpion