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Peptide record

TPDB31593

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB31593
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GGVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKAHGPTIGWCCKQ
Physicochemical Analysis
C212H325N63O62S6
EMFY
G
4940.66
7.65
5
2
13
+1
1.48
-0.033
65.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
341.55
15
Residue Composition
number
2
A
1
R
2
N
2
D
6
C
0
E
1
Q
9
G
2
H
3
I
3
L
2
K
0
M
0
F
4
P
4
S
2
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 1 G: 9 H: 2 I: 3 L: 3 K: 2 M: 0 F: 0 P: 4 S: 4 T: 2 W: 3 Y: 0 V: 2
Chemical Descriptors
48
C212H325N63O62S6
4940.66
7.65
+1
1.48
-0.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin has a great efficacy for Nav1.4/SCN4A (EC(50)=30.62 nM) and Nav1.5/SCN5A (EC(50)=62.5 nM). It is less potent on Nav1.6/SCN8A (EC(50)=about 300 nM), Nav1.1/SCN1A (EC(50)=390.55 nM), Nav1.3/SCN3A (EC(50)=459.36 nM) and Nav1.2/SCN2A (EC(50)=1998.00 nM) (when measured as the increase in the slow component). {ECO:0000269|PubMed:15169781}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura fuscoviridis (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation. This toxin has a great efficacy for Nav1.4/SCN4A (EC(50)=30.62 nM) and Nav1.5/SCN5A (EC(50)=62.5 nM).
Delta-actitoxin-Afv1b (Delta-AITX-Afv1b) (AFT-II) (AFII)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Afv1b (Delta-AITX-Afv1b) (AFT-II) (AFII)
sea anemone