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Peptide record

TPDB31544

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB31544
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GGCIKWNHSCQTTTLKCCGKCVVCYCHTPWGTNCRCDRTRLFCTED
Physicochemical Analysis
C216H337N67O65S10
AM
C
5233.06
7.96
8
3
9
+3
5.36
-0.354
38.04
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13115
250.62
22
Residue Composition
number
0
A
3
R
2
N
2
D
10
C
1
E
1
Q
4
G
2
H
1
I
2
L
3
K
0
M
1
F
1
P
1
S
7
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 2 C: 10 E: 1 Q: 1 G: 4 H: 2 I: 1 L: 2 K: 3 M: 0 F: 1 P: 1 S: 1 T: 7 W: 2 Y: 1 V: 2
Chemical Descriptors
46
C216H337N67O65S10
5233.06
7.96
+3
5.36
-0.354
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Competes for binding at site 3 of the insect voltage-gated sodium channel (Nav) (PubMed:12860384). Insecticidal neurotoxin (PubMed:12860384, PubMed:29247580). Causes temporary paralysis to lepidopteran larvae (10.3 nmol/g) or to crickets (doses from 0.93 to 119 ug/g) (PubMed:12860384, PubMed:29247580). Is not toxic to mice when injected intracranially (high doses) (PubMed:12860384, PubMed:29247580). {ECO:0000269|PubMed:12860384, ECO:0000269|PubMed:29247580}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Macrothele gigas (Japanese funnel web spider)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Competes for binding at site 3 of the insect voltage-gated sodium channel (Nav) (PubMed:12860384). Insecticidal neurotoxin (PubMed:12860384, PubMed:29247580).
Mu-hexatoxin-Mg2a (Mu-HXTX-Mg2a) (Neurotoxin magi-3)
spider
Neurotoxin 02 (plectoxin) family, 02 (plectoxin) subfamily
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 02 (plectoxin) subfamily
Mu-hexatoxin-Mg2a (Mu-HXTX-Mg2a) (Neurotoxin magi-3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:12860384}.
spider