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Peptide record

TPDB31522

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB31522
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GGCCSYPPCAVSNPQHC
Physicochemical Analysis
C69H103N21O23S4
RDEILKMFTW
C
1722.94
6.84
1
0
3
-0
1.59
-0.159
22.94
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
100.99
9
Residue Composition
number
1
A
0
R
1
N
0
D
4
C
0
E
1
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
3
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 4 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
17
C69H103N21O23S4
1722.94
6.84
-0
1.59
-0.159
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus ventricosus (Mediterranean cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Vn (Vn1A)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18266261}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Vn (Vn1A)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:18266261}.
cone snail