Back to search

Peptide record

TPDB31513

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB31513
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GGCCSHPACQNNPDYC
Physicochemical Analysis
C64H93N21O24S4
REILKMFTWV
C
1668.81
4.93
1
1
2
-1
2.59
-0.719
6.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
104.27
9
Residue Composition
number
1
A
0
R
2
N
1
D
4
C
0
E
1
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 4 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C64H93N21O24S4
1668.81
4.93
-1
2.59
-0.719
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin is an antagonist of all rat neuronal alpha-3-beta-2/CHRNA3-CHRNB2, alpha-4-beta-2/CHRNA4-CHRNB2 and alpha-7/CHRNA7 nAChR subtypes. {ECO:0000269|PubMed:20933537}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus tinianus (Variable cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin is an antagonist of all rat neuronal alpha-3-beta-2/CHRNA3-CHRNB2, alpha-4-beta-2/CHRNA4-CHRNB2 and alpha-7/CHRNA7 nAChR subtypes..
Alpha-conotoxin TiIA
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20933537}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin TiIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:20933537}.
cone snail