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Peptide record

TPDB31509

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB31509
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GGCCSHPACFASNPDYC
Physicochemical Analysis
C70H98N20O24S4
REQILKMTWV
C
1731.91
4.93
1
1
4
-1
0.42
-0.041
11.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
100.47
8
Residue Composition
number
2
A
0
R
1
N
1
D
4
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
1
F
2
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 1 C: 4 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C70H98N20O24S4
1731.91
4.93
-1
0.42
-0.041
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus anemone (Anemone cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like AnIC
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14971903}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like AnIC
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14971903}.
cone snail