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Peptide record

TPDB31505

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB31505
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GGCCSHPACAANNQDYC
Physicochemical Analysis
C65H96N22O25S4
REILKMFTWV
C
1713.85
4.93
1
1
4
-1
1.80
-0.371
17.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1740
101.53
9
Residue Composition
number
3
A
0
R
2
N
1
D
4
C
0
E
1
Q
2
G
1
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 2 D: 1 C: 4 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
17
C65H96N22O25S4
1713.85
4.93
-1
1.80
-0.371
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: [Alpha-conotoxin AnIB]: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic toxin blocks rat alpha-3beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.3 nM) and alpha-7/CHRNA7 nAChRs (IC(50)=76 nM). {ECO:0000269|PubMed:14971903}. FUNCTION: [Alpha-conotoxin AnIA]: This synthetic toxin blocks rat alpha-3-beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.2 nM). {ECO:0000269|PubMed:14971903}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus anemone (Anemone cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
[Alpha-conotoxin AnIB]: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic toxin blocks rat alpha-3beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.3 nM) and alpha-7/CHRNA7 nAChRs (IC(50)=76 nM).. FUNCTION: [Alpha-conotoxin AnIA]: This synthetic toxin blocks rat alpha-3-beta-2/CHRNA3-CHRNB2 nAChRs (IC(50)=0.2 nM)..
Alpha-conotoxin AnIB [Cleaved into: Alpha-conotoxin AnIA]
cone snail
Conotoxin A superfamily
Evidence at protein level
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14971903}.
Additional Detail Fields 7 fields
3D-structure Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Sulfation Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin AnIB [Cleaved into: Alpha-conotoxin AnIA]
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:14971903}.
cone snail