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Peptide record

TPDB31436

Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB31436
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GEDEYAEGIREYQLIHGKI
Physicochemical Analysis
C98H150N26O33
NCMFPSTWV
E
2220.42
4.35
3
5
7
-3
9.14
-0.911
87.37
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
134.21
3
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
4
E
1
Q
3
G
1
H
3
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 4 Q: 1 G: 3 H: 1 I: 3 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
19
C98H150N26O33
2220.42
4.35
-3
9.14
-0.911
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has highest potency for the NR2B/GRIN2B subunit. It induces sleep in 10-day-old mice when injected intracranially, and hyperactivity in 24-day-old mice. {ECO:0000269|PubMed:17962189}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus parius (Cone snail)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has highest potency for the NR2B/GRIN2B subunit.
Conantokin-Pr1 (Con-Pr1)
cone snail
Conotoxin B superfamily
Evidence at protein level
Calcium Direct protein sequencing Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
Additional Detail Fields 7 fields
Calcium Direct protein sequencing Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conotoxin B superfamily
Conantokin-Pr1 (Con-Pr1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
cone snail