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Peptide record

TPDB31422

Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB31422
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GEPEVAKWAEGLREKAASN
Physicochemical Analysis
C88H140N26O30
DCQHIMFTY
AE
2042.24
4.73
3
4
7
-1
8.87
-0.984
56.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
269.31
2
Residue Composition
number
4
A
1
R
1
N
0
D
0
C
4
E
0
Q
2
G
0
H
0
I
1
L
2
K
0
M
0
F
1
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 0 E: 4 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
19
C88H140N26O30
2042.24
4.73
-1
8.87
-0.984
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit. It induces sleep in 10-day-old mice when injected intracranially, and hyperactivity in 24-day-old mice. {ECO:0000269|PubMed:17962189}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus parius (Cone snail)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin has the highest potency for the NR2B/GRIN2B subunit.
Conantokin-Pr3 (Con-Pr3)
cone snail
Conotoxin B superfamily
Evidence at protein level
Amidation Calcium Direct protein sequencing Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
Additional Detail Fields 7 fields
Amidation Calcium Direct protein sequencing Gamma-carboxyglutamic acid Hydroxylation Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Magnesium Metal-binding Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conotoxin B superfamily
Conantokin-Pr3 (Con-Pr3)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17962189}.
cone snail