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Peptide record

TPDB31398

Neurotoxin Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB31398
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 8-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCPWEPWC
Physicochemical Analysis
C45H56N10O11S2
ARNDQHILKMFSTYV
CPW
977.12
3.29
0
1
2
-1
-1.25
-0.488
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11125
1138.55
2
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
8
C45H56N10O11S2
977.12
3.29
-1
-1.25
-0.488
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus leopardus (Leopard cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Le
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
Additional Detail Fields 7 fields
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Le
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
cone snail