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Peptide record

TPDB31343

Neurotoxin Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB31343
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 8-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCVLLPWC
Physicochemical Analysis
C41H63N9O9S2
ARNDEQHIKMFSTY
CL
890.13
5.18
0
0
4
-0
-2.92
1.738
133.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
631.93
2
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
8
C41H63N9O9S2
890.13
5.18
-0
-2.92
1.738
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus purpurascens (Purple cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Leu-contryphan-P
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10461743}.
Additional Detail Fields 7 fields
D-amino acid Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Leu-contryphan-P
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:10461743}.
cone snail