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Peptide record

TPDB31341

Neurotoxin Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB31341
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCVGHRKSCEHDKKNGCCYFMTCNCWHPMGQ
Physicochemical Analysis
C146H219N47O42S8
AIL
C
3561.11
8.03
7
2
6
+2
6.34
-0.787
9.35
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7365
206.82
12
Residue Composition
number
0
A
1
R
2
N
1
D
6
C
1
E
1
Q
4
G
3
H
0
I
0
L
3
K
2
M
1
F
1
P
1
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 6 E: 1 Q: 1 G: 4 H: 3 I: 0 L: 0 K: 3 M: 2 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
31
C146H219N47O42S8
3561.11
8.03
+2
6.34
-0.787
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1)..
U6-ctenitoxin-Co1a (U6-CNTX-Co1a) (Neurotoxin Oc F35-5)
spider
Neurotoxin 02 (plectoxin) family, 09 subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 02 (plectoxin) family, 09 subfamily
U6-ctenitoxin-Co1a (U6-CNTX-Co1a) (Neurotoxin Oc F35-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
spider