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Peptide record

TPDB31303

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB31303
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCKKDRKPCSYQADCCNCCPIGTCAPSTNWILPGCSTGPFMAR
Physicochemical Analysis
C190H300N56O58S9
EHV
C
4585.35
8.10
5
2
10
+3
3.81
-0.270
34.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
163.35
18
Residue Composition
number
3
A
2
R
2
N
2
D
8
C
0
E
1
Q
4
G
0
H
2
I
1
L
3
K
1
M
1
F
5
P
3
S
3
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 2 C: 8 E: 0 Q: 1 G: 4 H: 0 I: 2 L: 1 K: 3 M: 1 F: 1 P: 5 S: 3 T: 3 W: 1 Y: 1 V: 0
Chemical Descriptors
43
C190H300N56O58S9
4585.35
8.10
+3
3.81
-0.270
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus striatus (Striated cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like S11.2
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like S11.2
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail