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Peptide record

TPDB31301

Neurotoxin Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB31301
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 41-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCKKDRKPCSYHADCCNCCLSGICAPSTNWILPGCSTSTFT
Physicochemical Analysis
C181H284N52O58S8
EQMV
C
4373.04
7.85
5
2
9
+2
2.71
-0.132
42.93
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
171.28
20
Residue Composition
number
2
A
1
R
2
N
2
D
8
C
0
E
0
Q
3
G
1
H
2
I
2
L
3
K
0
M
1
F
3
P
5
S
4
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 8 E: 0 Q: 0 G: 3 H: 1 I: 2 L: 2 K: 3 M: 0 F: 1 P: 3 S: 5 T: 4 W: 1 Y: 1 V: 0
Chemical Descriptors
41
C181H284N52O58S8
4373.04
7.85
+2
2.71
-0.132
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Both natural (L-Thr form) and synthetic (D-Thr form) peptides cause paralysis and death following intracranial injection and grooming and hypersensitivity upon intraperitoneal injection into mice. The L-Thr form of the peptide is 7-fold more potent than the D-Thr form. Both natural peptide (L-Thr form) and synthetic peptide (D-Thr form) are active on nerve, and on muscle. {ECO:0000250, ECO:0000269|PubMed:17996262}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels (By similarity). Both natural (L-Thr form) and synthetic (D-Thr form) peptides cause paralysis and death following intracranial injection and grooming and hypersensitivity upon intraperitoneal injection into mice.
Iota-conotoxin-like r11d (R11.8)
cone snail
Conotoxin I1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin I1 superfamily
Iota-conotoxin-like r11d (R11.8)
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail