Back to search

Peptide record

TPDB31299

Neurotoxin Toxicity standard
43 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB31299
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 43-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCKKDRKPCSYHADCCNCCLSGICAPSTNWILPGCSTSSFFKI
Physicochemical Analysis
C197H307N55O59S8
EQMV
C
4646.42
8.10
6
2
11
+3
2.11
-0.033
50.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7490
161.20
19
Residue Composition
number
2
A
1
R
2
N
2
D
8
C
0
E
0
Q
3
G
1
H
3
I
2
L
4
K
0
M
2
F
3
P
6
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 2 C: 8 E: 0 Q: 0 G: 3 H: 1 I: 3 L: 2 K: 4 M: 0 F: 2 P: 3 S: 6 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
43
C197H307N55O59S8
4646.42
8.10
+3
2.11
-0.033
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus figulinus (Fig cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like Fi11.6
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
Bromination D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
Bromination D-amino acid Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like Fi11.6
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail