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Peptide record

TPDB31282

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB31282
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCKDNFSANTCKHVKANNNCGSQKYATNCAKTCGKC
Physicochemical Analysis
C152H247N51O52S6
REILMPW
NCK
3813.30
8.88
7
1
7
+5
7.82
-0.878
19.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
48.91
19
Residue Composition
number
4
A
0
R
6
N
1
D
6
C
0
E
1
Q
3
G
1
H
0
I
0
L
6
K
0
M
1
F
0
P
2
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 6 D: 1 C: 6 E: 0 Q: 1 G: 3 H: 1 I: 0 L: 0 K: 6 M: 0 F: 1 P: 0 S: 2 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
36
C152H247N51O52S6
3813.30
8.88
+5
7.82
-0.878
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-dependent potassium channels (Kv1/KCNA). Inhibits the binding of 125I-alpha-dendrotoxin to rat synaptosomal membranes (IC(50)=22 nM). {ECO:0000269|PubMed:9613617}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Actinia equina (Beadlet anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibits voltage-dependent potassium channels (Kv1/KCNA). Inhibits the binding of 125I-alpha-dendrotoxin to rat synaptosomal membranes (IC(50)=22 nM)..
Kappa-actitoxin-Aeq4a (Kappa-AITX-Aeq4a) (Potassium channel toxin Aek)
sea anemone
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemone type 1 potassium channel toxin family, Type 1b subfamily
Kappa-actitoxin-Aeq4a (Kappa-AITX-Aeq4a) (Potassium channel toxin Aek)
sea anemone