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Peptide record

TPDB31275

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB31275
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCIPYGKTCEFWSGPWCCAGKCKLNVWSMTLSCTRNF
Physicochemical Analysis
C185H274N48O49S7
DQH
C
4178.92
8.31
4
1
12
+3
-3.56
0.016
42.16
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18365
439.47
15
Residue Composition
number
1
A
1
R
2
N
0
D
6
C
1
E
0
Q
4
G
0
H
1
I
2
L
3
K
1
M
2
F
2
P
3
S
3
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 2 K: 3 M: 1 F: 2 P: 2 S: 3 T: 3 W: 3 Y: 1 V: 1
Chemical Descriptors
37
C185H274N48O49S7
4178.92
8.31
+3
-3.56
0.016
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks the Nav1.2/SCN2A, Nav1.4/SCN4A, and Nav1.6/SCN8A sodium channels. Reduces the peak amplitude of the sodium current and negatively shifts the steady-state inactivation process. Does not shift the threshold potential of activation or the voltage corresponding to maximal current. Does not change the reversal potential of the sodium current. May act on site 1 of the receptor. {ECO:0000269|PubMed:18606177, ECO:0000269|Ref.2}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heriaeus mellotteei (Crab spider) (Heriaeus oblongus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks the Nav1.2/SCN2A, Nav1.4/SCN4A, and Nav1.6/SCN8A sodium channels. Reduces the peak amplitude of the sodium current and negatively shifts the steady-state inactivation process.
Mu-thomitoxin-Hme1a (Mu-TMTX-Hme1a) (Neurotoxin Hm-1)
spider
Neurotoxin 01 (U2-agtx) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 01 (U2-agtx) family
Mu-thomitoxin-Hme1a (Mu-TMTX-Hme1a) (Neurotoxin Hm-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider