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Peptide record

TPDB31273

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB31273
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCIPSFGECAWFSGESCCTGICKWVFFTSKFMCRRVWGKD
Physicochemical Analysis
C205H296N52O53S7
NQHLY
C
4561.34
8.02
5
3
14
+2
-2.36
0.200
36.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
369.96
12
Residue Composition
number
1
A
2
R
0
N
1
D
6
C
2
E
0
Q
5
G
0
H
2
I
0
L
3
K
1
M
5
F
1
P
4
S
2
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 6 E: 2 Q: 0 G: 5 H: 0 I: 2 L: 0 K: 3 M: 1 F: 5 P: 1 S: 4 T: 2 W: 3 Y: 0 V: 2
Chemical Descriptors
40
C205H296N52O53S7
4561.34
8.02
+2
-2.36
0.200
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks the Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A sodium channels. Shows a slight preference for the Nav1.2 and Nav1.4 channels. Reduces the peak amplitude of the sodium current and negatively shifts the steady-state inactivation process. Does not shift the threshold potential of activation or the voltage corresponding to maximal current. Does not change the reversal potential of the sodium current. May act on site 1 of the receptor. {ECO:0000269|PubMed:18606177, ECO:0000269|Ref.2}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Heriaeus mellotteei (Crab spider) (Heriaeus oblongus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Blocks the Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A and Nav1.6/SCN8A sodium channels. Shows a slight preference for the Nav1.2 and Nav1.4 channels.
Mu-thomitoxin-Hme1b (Mu-TMTX-Hme1b) (Neurotoxin Hm-2)
spider
Neurotoxin 19 (CSTX) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 19 (CSTX) family
Mu-thomitoxin-Hme1b (Mu-TMTX-Hme1b) (Neurotoxin Hm-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider