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Peptide record

TPDB31268

Neurotoxin Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB31268
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 19-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCIGRNESQKKDNVYKFKE
Physicochemical Analysis
C96H155N29O31S1
AHLMPTW
K
2243.52
9.55
5
3
4
+2
9.06
-1.579
35.79
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
66.41
6
Residue Composition
number
0
A
1
R
2
N
1
D
1
C
2
E
1
Q
2
G
0
H
1
I
0
L
4
K
0
M
1
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 1 C: 1 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 4 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
19
C96H155N29O31S1
2243.52
9.55
+2
9.06
-1.579
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Antagonist of L-type calcium channels (Cav1/CACNA1). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Antagonist of L-type calcium channels (Cav1/CACNA1)..
U7-ctenitoxin-Pn1b (U7-CNTX-Pn1b) (Neurotoxin Tx3)
spider
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 6 fields
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
U7-ctenitoxin-Pn1b (U7-CNTX-Pn1b) (Neurotoxin Tx3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider