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Peptide record

TPDB31265

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB31265
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCIEIGGDCDGYQEKSYCQCCRNNGFCS
Physicochemical Analysis
C121H182N36O45S6
AHLMPTWV
C
3053.35
4.06
2
4
5
-2
5.54
-0.564
27.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
3355
109.88
14
Residue Composition
number
0
A
1
R
2
N
2
D
6
C
2
E
2
Q
5
G
0
H
2
I
0
L
1
K
0
M
1
F
0
P
2
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 2 C: 6 E: 2 Q: 2 G: 5 H: 0 I: 2 L: 0 K: 1 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
28
C121H182N36O45S6
3053.35
4.06
-2
5.54
-0.564
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically. Potent blocker of N-type calcium channels (Cav2.2/CACNA1B).

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Omega-agatoxin are antagonist of voltage-gated calcium channels. They block insect neuromuscular transmission presynaptically.
Omega-agatoxin-Aa2a (Omega-AGTX-Aa2a) (Omega-agatoxin IIA) (Omega-Aga-IIA) (Omega-agatoxin-2A)
spider
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Ion channel impairing toxin Neurotoxin Presynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Presynaptic neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily
Omega-agatoxin-Aa2a (Omega-AGTX-Aa2a) (Omega-agatoxin IIA) (Omega-Aga-IIA) (Omega-agatoxin-2A)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider