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Peptide record

TPDB31244

Neurotoxin Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB31244
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 40-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GCGDINAACKSDCDCCGNSVTCDCYFTDCKCRESAIRKQF
Physicochemical Analysis
C171H270N52O62S9
HLMPW
C
4334.88
4.64
5
6
9
-1
8.46
-0.295
34.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
45.91
18
Residue Composition
number
3
A
2
R
2
N
5
D
9
C
1
E
1
Q
3
G
0
H
2
I
0
L
3
K
0
M
2
F
0
P
3
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 5 C: 9 E: 1 Q: 1 G: 3 H: 0 I: 2 L: 0 K: 3 M: 0 F: 2 P: 0 S: 3 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
40
C171H270N52O62S9
4334.88
4.64
-1
8.46
-0.295
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects. {ECO:0000250|UniProtKB:P59367}.

Target

voltage-gated sodium channel (Nav) glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav). In vivo, is highly toxic to insects..
U12-ctenitoxin-Co1a (U12-CNTX-Co1a) (Neurotoxin Oc M14-5)
spider
Neurotoxin 03 (Tx2) family, 05 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Knottin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 03 (Tx2) family, 05 subfamily
U12-ctenitoxin-Co1a (U12-CNTX-Co1a) (Neurotoxin Oc M14-5)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider