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Peptide record

TPDB31240

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB31240
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GAPCLCANSGPNTRGNDLNGIVWVFGCPSGWHDCHGRAMVGYCCQED
Physicochemical Analysis
C208H308N64O65S7
K
G
4969.54
5.16
4
4
14
-2
4.17
-0.223
49.79
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
258.88
15
Residue Composition
number
3
A
2
R
4
N
3
D
6
C
1
E
1
Q
8
G
2
H
1
I
2
L
0
K
1
M
1
F
3
P
2
S
1
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 2 N: 4 D: 3 C: 6 E: 1 Q: 1 G: 8 H: 2 I: 1 L: 2 K: 0 M: 1 F: 1 P: 3 S: 2 T: 1 W: 2 Y: 1 V: 3
Chemical Descriptors
47
C208H308N64O65S7
4969.54
5.16
-2
4.17
-0.223
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. {ECO:0000250|UniProtKB:P01533}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anemonia erythraea (Sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction..
Delta-actitoxin-Aer1a (Delta-AITX-Aer1a) (AETX I) (Toxin AETX-1)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Aer1a (Delta-AITX-Aer1a) (AETX I) (Toxin AETX-1)
sea anemone