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Peptide record

TPDB31181

Neurotoxin Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB31181
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCCSRPPCIANNPDIC
Physicochemical Analysis
C65H107N21O22S4
EQHLKMFTWYV
C
1662.93
5.80
1
1
3
-0
2.62
-0.013
55.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
250
15.03
7
Residue Composition
number
1
A
1
R
2
N
1
D
4
C
0
E
0
Q
1
G
0
H
2
I
0
L
0
K
0
M
0
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C65H107N21O22S4
1662.93
5.80
-0
2.62
-0.013
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin Tx1C (Alpha-conotoxin-like 1)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin Tx1C (Alpha-conotoxin-like 1)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:19380747}.
cone snail