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Peptide record

TPDB31038

Neurotoxin Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB31038
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 12-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCCSDPRCKHQC
Physicochemical Analysis
C49H81N19O17S4
ANEILMFTWYV
C
1336.54
7.85
3
1
0
+1
4.20
-0.950
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
250
18.71
6
Residue Composition
number
0
A
1
R
0
N
1
D
4
C
0
E
1
Q
1
G
1
H
0
I
0
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 4 E: 0 Q: 1 G: 1 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C49H81N19O17S4
1336.54
7.85
+1
4.20
-0.950
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250|UniProtKB:P50983}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus regius (Crown cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Reg1b/Reg1c
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17153339}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Reg1b/Reg1c
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:17153339}.
cone snail