Back to search

Peptide record

TPDB31003

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB31003
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GCTPEYCSMWCKVKVSQNYCVKNCKCPGR
Physicochemical Analysis
C139H220N40O40S7
ADHILF
C
3315.94
8.57
5
1
7
+4
4.34
-0.497
30.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
267.04
14
Residue Composition
number
0
A
1
R
2
N
0
D
6
C
1
E
1
Q
2
G
0
H
0
I
0
L
4
K
1
M
0
F
2
P
2
S
1
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 2 H: 0 I: 0 L: 0 K: 4 M: 1 F: 0 P: 2 S: 2 T: 1 W: 1 Y: 2 V: 3
Chemical Descriptors
29
C139H220N40O40S7
3315.94
8.57
+4
4.34
-0.497
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels. {ECO:0000269|PubMed:16405970}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus trivittatus (Argentinean scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reduces potassium currents through Kv1.2/KCNA2 and Kv1.3/KCNA3 voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 20.1 (Toxin Tt28)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily
Potassium channel toxin alpha-KTx 20.1 (Toxin Tt28)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion