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Peptide record

TPDB30899

Neurotoxin Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB30899
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 48-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GASCRCDSDGPTSRGDTLTGTLWLIGRCPSGWHNCRGSGPFIGYCCKQ
Physicochemical Analysis
C212H327N67O67S6
EMV
G
5078.70
8.02
6
3
10
+2
2.85
-0.435
42.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
253.31
18
Residue Composition
number
1
A
4
R
1
N
3
D
6
C
0
E
1
Q
9
G
1
H
2
I
3
L
1
K
0
M
1
F
3
P
5
S
4
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 3 C: 6 E: 0 Q: 1 G: 9 H: 1 I: 2 L: 3 K: 1 M: 0 F: 1 P: 3 S: 5 T: 4 W: 2 Y: 1 V: 0
Chemical Descriptors
48
C212H327N67O67S6
5078.70
8.02
+2
2.85
-0.435
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Has effect on SCN4A/SCN1B, and SCN5A/SCN1B, has no effect on SCN2A/SCN1B, and SCN10A/SCN1B. Possesses the highest efficacy for the insect sodium channel para/tipE. Also interacts with sodium channels in cardiac cells. Shows lethality to crabs (PubMed:22015268). {ECO:0000269|PubMed:11704639, ECO:0000269|PubMed:12459477, ECO:0000269|PubMed:7911468}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bunodosoma granuliferum (Red warty sea anemone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds voltage-dependently at site 3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Has effect on SCN4A/SCN1B, and SCN5A/SCN1B, has no effect on SCN2A/SCN1B, and SCN10A/SCN1B.
Delta-actitoxin-Bgr2b (Delta-AITX-Bgr2b) (Bg III) (BgIII) (Neurotoxin Bg-3)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at protein level
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Bgr2b (Delta-AITX-Bgr2b) (Bg III) (BgIII) (Neurotoxin Bg-3)
sea anemone