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Peptide record

TPDB30896

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB30896
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GAVPCGKDGRQCRNHADCCNCCPIGTCAPSTNWILPGCSTGQFMTR
Physicochemical Analysis
C195H310N64O62S9
EY
C
4831.54
7.85
5
2
10
+2
5.19
-0.263
38.26
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6000
124.18
19
Residue Composition
number
3
A
3
R
3
N
2
D
8
C
0
E
2
Q
6
G
1
H
2
I
1
L
1
K
1
M
1
F
4
P
2
S
4
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 3 N: 3 D: 2 C: 8 E: 0 Q: 2 G: 6 H: 1 I: 2 L: 1 K: 1 M: 1 F: 1 P: 4 S: 2 T: 4 W: 1 Y: 0 V: 1
Chemical Descriptors
46
C195H310N64O62S9
4831.54
7.85
+2
5.19
-0.263
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus magus (Magical cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like M11.1
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.5
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like M11.1 Iota-conotoxin-like R11.5
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail