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Peptide record

TPDB30892

Neurotoxin Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB30892
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 46-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GAVPCGKDGRQCRNHADCCNCCPFGTCAPSTNRILPGCSTGMFLTR
Physicochemical Analysis
C194H313N65O61S9
EWY
C
4820.56
8.10
6
2
10
+3
5.89
-0.220
38.26
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
500
10.37
18
Residue Composition
number
3
A
4
R
3
N
2
D
8
C
0
E
1
Q
6
G
1
H
1
I
2
L
1
K
1
M
2
F
4
P
2
S
4
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 4 N: 3 D: 2 C: 8 E: 0 Q: 1 G: 6 H: 1 I: 1 L: 2 K: 1 M: 1 F: 2 P: 4 S: 2 T: 4 W: 0 Y: 0 V: 1
Chemical Descriptors
46
C194H313N65O61S9
4820.56
8.10
+3
5.89
-0.220
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity). {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus radiatus (Rayed cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Iota-conotoxins bind to voltage-gated sodium channels (Nav) and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. Produces general excitatory symptoms (By similarity)..
Iota-conotoxin-like R11.18
cone snail
Conotoxin I1 superfamily
Evidence at transcript level
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct.
Additional Detail Fields 7 fields
D-amino acid Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Conotoxin I1 superfamily
Iota-conotoxin-like R11.18
TISSUE SPECIFICITY: Expressed by the venom duct.
cone snail