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Peptide record

TPDB30876

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB30876
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
GAACFCDSDGPSVSGNTLSGILWLAGCPSGWHNCKAHGPNIGWCCKK
Physicochemical Analysis
C207H310N60O61S6
REQMY
G
4807.46
7.65
5
2
14
+1
-0.20
-0.030
56.17
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16875
351.02
15
Residue Composition
number
4
A
0
R
3
N
2
D
6
C
0
E
0
Q
8
G
2
H
2
I
3
L
3
K
0
M
1
F
3
P
5
S
1
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 2 C: 6 E: 0 Q: 0 G: 8 H: 2 I: 2 L: 3 K: 3 M: 0 F: 1 P: 3 S: 5 T: 1 W: 3 Y: 0 V: 1
Chemical Descriptors
47
C207H310N60O61S6
4807.46
7.65
+1
-0.20
-0.030
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction. {ECO:0000250|UniProtKB:P10454}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Anthopleura xanthogrammica (Giant green sea anemone) (Actinia xanthogrammica)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction..
Delta-actitoxin-Axm1d (Delta-AITX-Axm1d) (PCR2-1) (Toxin PCR3)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Evidence at transcript level
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Cardiotoxin Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at transcript level
Sea anemone sodium channel inhibitory toxin family, Type I subfamily
Delta-actitoxin-Axm1d (Delta-AITX-Axm1d) (PCR2-1) (Toxin PCR3)
sea anemone