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Peptide record

TPDB30655

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB30655
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FHGGSWYRFPWGY
Physicochemical Analysis
C84H98N20O17
ANDCEQILKMTV
G
1659.83
9.63
2
0
6
+1
-5.46
-0.777
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
13980
842.26
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
1
H
0
I
0
L
0
K
0
M
2
F
1
P
1
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 1 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
13
C84H98N20O17
1659.83
9.63
+1
-5.46
-0.777
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits non-inactivating voltage-gated potassium channels in rat dorsal root ganglion neurons. {ECO:0000269|PubMed:15081394}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus monile (Necklace cone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibits non-inactivating voltage-gated potassium channels in rat dorsal root ganglion neurons..
Kappa-conotoxin Mo1659
cone snail
Evidence at protein level
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:15081394}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Kappa-conotoxin Mo1659
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:15081394}.
cone snail