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Peptide record

TPDB30639

Neurotoxin Toxicity standard
49 amino acids
Basic Information
3D PDB MODEL
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TPDB30639
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 49-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
FFECTFECDIKKEGKPCKPKGCKCKDKDNKDHKKCSGGWRCKLKLCLKF
Physicochemical Analysis
C251H404N70O67S8
AQMYV
K
5730.88
9.21
16
7
9
+8
17.96
-1.029
31.84
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6000
104.70
11
Residue Composition
number
0
A
1
R
1
N
4
D
8
C
3
E
0
Q
4
G
1
H
1
I
3
L
14
K
0
M
4
F
2
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 4 C: 8 E: 3 Q: 0 G: 4 H: 1 I: 1 L: 3 K: 14 M: 0 F: 4 P: 2 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
49
C251H404N70O67S8
5730.88
9.21
+8
17.96
-1.029
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Toxin that causes irreversible contractile paralysis into adult Aedes aegypti resulting in 100% mortality after 24 hours. {ECO:0000250|UniProtKB:P0DRD8}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lasiodora parahybana (Brazilian salmon pink birdeater) (Brazilian salmon pink tarantula)
Neurotoxin
Toxin that causes irreversible contractile paralysis into adult Aedes aegypti resulting in 100% mortality after 24 hours..
U1-theraphotoxin-Lp1a (U1-TRTX-Lp1a) (Lasiotoxin-1) (LpTX1)
spider
Neurotoxin 12 (Hwtx-2) family, 04 (lasiotoxin) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Toxin that causes irreversible contractile paralysis into adult Aedes aegypti resulting in 100% mortality after 24 hours. {ECO:0000269|PubMed:37505687}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Lasiodora klugi (Bahia scarlet tarantula) (Mygale klugii)
Neurotoxin
Toxin that causes irreversible contractile paralysis into adult Aedes aegypti resulting in 100% mortality after 24 hours..
U-theraphotoxin-Lk2a (U-TRTX-Lk2a)
spider
Neurotoxin 12 (Hwtx-2) family, 04 (lasiotoxin) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37505687}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 04 (lasiotoxin) subfamily
U1-theraphotoxin-Lp1a (U1-TRTX-Lp1a) (Lasiotoxin-1) (LpTX1) U-theraphotoxin-Lk2a (U-TRTX-Lk2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}. TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:37505687}.
spider