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Peptide record

TPDB30635

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB30635
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FECSISCEIEKKGESCKPKKCKGGWKCKFNMCVKV
Physicochemical Analysis
C172H282N46O48S7
ARDQHLTY
K
3986.83
8.87
9
4
8
+5
12.02
-0.537
38.86
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5875
147.36
10
Residue Composition
number
0
A
0
R
1
N
0
D
6
C
4
E
0
Q
3
G
0
H
2
I
0
L
9
K
1
M
2
F
1
P
3
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 6 E: 4 Q: 0 G: 3 H: 0 I: 2 L: 0 K: 9 M: 1 F: 2 P: 1 S: 3 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
35
C172H282N46O48S7
3986.83
8.87
+5
12.02
-0.537
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I. Paralyzes locusts and kills mice following intracerebroventricular injection.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)
Neurotoxin Postsynaptic neurotoxin
Blocks neuromuscular transmission. Acts cooperatively to potentiate the activity of huwentoxin-I.
U1-theraphotoxin-Hs1f (U1-TRTX-Hs1f) (Huwentoxin-8) (Huwentoxin-VIII) (HwTx-VIII)
spider
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin
Evidence at protein level
Neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily
U1-theraphotoxin-Hs1f (U1-TRTX-Hs1f) (Huwentoxin-8) (Huwentoxin-VIII) (HwTx-VIII)
TISSUE SPECIFICITY: Expressed by the venom gland.
spider