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Peptide record

TPDB30627

Neurotoxin Toxicity standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB30627
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 41-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
FDGRNAAPSDKASDLISLAVRGCCSHPACSGNNPYFCGGKR
Physicochemical Analysis
C177H277N57O57S4
EQMTW
AGS
4243.73
8.30
6
3
12
+2
6.00
-0.407
47.80
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1740
41.00
13
Residue Composition
number
5
A
3
R
3
N
3
D
4
C
0
E
0
Q
5
G
1
H
1
I
2
L
2
K
0
M
2
F
3
P
5
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 3 N: 3 D: 3 C: 4 E: 0 Q: 0 G: 5 H: 1 I: 1 L: 2 K: 2 M: 0 F: 2 P: 3 S: 5 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
41
C177H277N57O57S4
4243.73
8.30
+2
6.00
-0.407
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Lt1.3-II (C1-C3 C2-C4): Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin potently and selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=44.8 nM) nAChRs. {ECO:0000269|PubMed:29614714}. FUNCTION: Lt1.3-I (C1-C4 C2-C3): This isomer inhibits GABABRec-coupled Cav2.2/CACNA1B but has no activity on nAChRs. {ECO:0000269|PubMed:29614714}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus litteratus (Lettered cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Lt1.3-II (C1-C3 C2-C4): Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin potently and selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=44.8 nM) nAChRs.. FUNCTION: Lt1.3-I (C1-C4 C2-C3): This isomer inhibits GABABRec-coupled Cav2.2/CACNA1B but has no activity on nAChRs..
Alpha-conotoxin Lt1.3 b
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29614714}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Calcium channel impairing toxin Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin Voltage-gated calcium channel impairing toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Calcium channel impairing toxin Ion channel impairing toxin Voltage-gated calcium channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin Lt1.3 b
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29614714}.
cone snail