Back to search

Peptide record

TPDB30554

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB30554
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
EVDMRCKSSKECLVKCKQATGRPNGKCMNRKCKCYPR
Physicochemical Analysis
C173H301N59O51S8
HIFW
K
4280.14
9.83
11
3
7
+8
14.75
-1.111
28.92
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
1865
43.57
13
Residue Composition
number
1
A
4
R
2
N
1
D
6
C
2
E
1
Q
2
G
0
H
0
I
1
L
7
K
2
M
0
F
2
P
2
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 2 D: 1 C: 6 E: 2 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 7 M: 2 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
37
C173H301N59O51S8
4280.14
9.83
+8
14.75
-1.111
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversibly blocks voltage-gated potassium channels (Kv1.1/KCNA1 (Kd=79 uM), Kv1.2/KCNA2 (Kd=547 nM) and Kv1.3/KCNA3 (Kd=492 nM)). {ECO:0000269|PubMed:11952787}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Parabuthus transvaalicus (Transvaal thick-tailed scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversibly blocks voltage-gated potassium channels (Kv1.1/KCNA1 (Kd=79 uM), Kv1.2/KCNA2 (Kd=547 nM) and Kv1.3/KCNA3 (Kd=492 nM))..
Potassium channel toxin alpha-KTx 1.10 (Parabutoxin-3) (PBTx3)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily
Potassium channel toxin alpha-KTx 1.10 (Parabutoxin-3) (PBTx3)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion